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This report captures the E-discussion on the Socio-economic Impact of HIV on Women and Girls, conducted on the Asia Pacific Community of Practice on HIV, Gender, and Human Rights (HIV-APCoP) from 1 to 22 August 2011. The e-discussion, based on initial findings of the soon to be published UNDP report The Socio-Economic Impact of HIV at the Household Level in Asia: A Regional Analysis of the Impact on Women and Girls, leveraged on the expertise and experience of the HIV-APCoP members to i) understand the critical socio-economic impacts of HIV on women and girls; ii) to explore in-depth impact mitigation possibilities; and iii) to consolidate knowledge on gaps and best practices in existing social protection strategies and schemes. Contributions were received from government, civil society, academia, and the UN family from across the Asia-Pacific region.